Development of a mechanism and an accurate and simple mathematical model for the description of drug release: Application to a relevant example of acetazolamide-controlled release from a bio-inspired elastin-based hydrogel

ALICIA FERNANDEZ COLINO; JOSE M. BERMUDEZ; ARIAS VALLEJO JAVIER; DANIELA QUINTEROS; GONZO

MATERIALS SCIENCE & ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2016 vol. 61 p. 286 - 292

0928-4931

Transversality between mathematical modeling, pharmacology, and materials science is essential inorder to achieve controlled-release systems with advanced properties. In this regard, the area ofbiomaterials provides a platform for the development of depots that are able to achieve controlledrelease of a drug, whereas pharmacology strives to find new therapeutic molecules and mathematicalmodels have a connecting function, providing a rational understanding by modeling the parametersthat influence the release observed. Herein we present a mechanism which, based on reasonableassumptions, explains the experimental data obtained very well. In addition, we have developed asimple and accurate ?lumped? kinetics model to correctly fit the experimentally observed drugreleasebehavior. This lumped model allows us to have simple analytic solutions for the mass andrate of drug release as a function of time without limitations of time or mass of drug released,which represents an important step-forward in the area of in vitro drug delivery whencompared to the current state of the art in mathematical modeling. As an example, we appliedthe mechanism and model to the release data for acetazolamide from a recombinant polymer. Bothmaterials were selected because of a need to develop a suitable ophthalmic formulation for thetreatment of glaucoma. The in vitro release model proposed herein provides a valuable predictivetool for ensuring product performance and batch-to-batch reproducibility, thus paving the way for thedevelopment of further pharmaceutical devices.