Starch-based antioxidants formulations for pharmaceutical purposes

GRAFIA, A.; GONZALEZ N; LÓPEZ OV; RAMIREZ RIGO MV; PACHECO C.; RAZUC M

Studies in Natural Products Chemistry

Elsevier

Año: 2024; p. 1 - 500

Natural antioxidants are attractivecompounds for the development of pharmaceutical products, mainly due to theirfree radical-stabilizing activity. This group of molecules is diverse in termsof structure, type of activity, and physical-chemical properties. Among them,vitamins (for example, C and E), carotenoids, and polyphenols can be mentioned.These compounds can be obtained from different natural sources (fungi,bacteria, algae, and plants), as well as from agro-industrial residues. Toformulate different pharmaceutical forms, extracts, isolated compounds, or encapsulated ingredients are used. This chapterfocuses on reviewing different types of raw materials to obtain naturalantioxidants, extraction and drying processes, dosage forms, and criticalquality controls of antioxidant starch-based products. The pharmaceuticalrelevance of starch as an excipient derives from its natural origin, worldwideavailability, relatively low cost, drug compatibility, and regulatory status.Different types and grades of starch with differentiated physicochemicalproperties that allow formulating a wide variety of antioxidant products, suchas suspensions, powders and microcapsules, granules, tablets, films, and gels,are presented. Complementarily, the characterization of these products ispresented. In this way, environmentally friendly techniques and methods areemphasized to showcase insights into sustainable design in the pharmaceutical field. Estado: Aceptado.