INVESTIGADORES
MESSINA German Alejandro
congresos y reuniones científicas
Título:
Determination of estrogenic endocrine disruptor: ethinylestradiol, using modified magnetic nanoparticles
Autor/es:
MARTÍNEZ NA; FERNÁNDEZ-BALDO MA; BERTOLINO FA; SANZ MI; MESSINA GA; RABA J
Reunión:
Congreso; 1ª Reunión Internacional de Ciencias Farmacéuticas, Córdoba, Argentina, 24 y 25 de Junio de 2010.; 2010
Resumen:
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Ethinylestradiol
(EE2) is a synthetic estrogen female sex hormone which is used as a
contraceptive therapy. The determination of synthetic estrogen has attracted
much attention since these compounds were included in the endocrine disrupting
chemicals (EDCs) and its able to cause the deleterious reproductive dysfunction of
animals and humans (1). Due the problems mentioned previously, is important the determination of EE2 in
water samples. Therefore we present a method that combined the use of
magnetic nanoparticles (MNPs) modified with anti-EE2 antibodies and square-wave
voltammetry (OSWV). The advance in experimental
electrochemical techniques in the field of analysis of drugs is due to their
simplicity, low cost and relatively short time of analysis when they are compared
with the other techniques (2-7). In addition the use of MNPs also have attracted great interest for biological and clinical applications (811), and they are widely used as a new agent of
preconcentration due to its features, between these: large surface area (12), strong magnetism, improve the adsorption capacity of
analytes and avoid the time-consuming enrichment process of loading large
volume samples through the rapid isolation of NPs with an adscititious magnet.