LPS induces Ciclooxygenase-2 expression in Y1 adrenal cells: involvement of PI3K/Akt and p38 MAPK signaling pathways

MARÍA E MERCAU; ELIAN F GIORDANINO; FRANCISCO ASTORT; NICOLÁS BENFATTO; JUAN M OLEJARCZYK; OMAR A. COSO ; CORA B CYMERYNG

Los Cocos

Simposio; SISTAM: The second South American Spring Symposium in Signal Transduction and Molecular Medicine? (SISTAM2012) 2th and 4th of Nobember. Bariloche, Río Negro, Argentina.; 2012

SISTAM

Previous studies from our laboratory have shown that LPS treatment stimulates adrenal steroid synthesis in Y1 cells, by a mechanism involving NFkB-dependent COX-2 activation. Present studies were designed to further describe the signaling cascades that lead to COX-2 induction, focusing on p38 MAPKs and PI3K/AKT signaling pathways. Our results showed that LPS treatment of Y1 cells significantly induces p38 MAPK and AKT phosphorylation (p