EFFECT OF RESPIRABLE DUST EMITTED FROM UNPAVED RURAL ROADS ON SKIN AND INNATE IMMUNE RESPONSE

CAMILA AZZI1 ; FENOY IGNACIO1 ; TATIANA ULCHAK 1 ; ORONA NADIA S. 1 .; VALENTINA MARTIN 1 , RAMIREZ HABERKON NANCY B. 2 , MENDEZ MARIANO 2 , PANEBIANCO JUAN E. 2 , GOLDMAN ALEJANDRA 1 , ASTORT FRANCISCO 1; ASTORT F

Congreso; Reunión anual de sociedades de biociencia; 2022

Environmental factors such as air particulate matter (PM) are involved in the development of allergic disorders like atopic dermatitis. The increase of allergicdiseases observed in rural areas may be a consequence of respiratory and dermal exposure to air PM containing inorganic and organic soil elements as wellas agrochemicals. The main source of rural PM is wind erosion of soils used for intensive cultivation. Also unpaved rural roads are an important source of PMemission. Although several studies related the exposure to urban PM with the onset or exacerbation of allergies such as atopic dermatitis, there are few studiesthat link rural PM with the development of allergic disorders.Our objective was to study the effect on innate immune response of PM emitted from unpaved roads from intensive cultivation areas where the useof agrochemicals prevails.