INVESTIGADORES
ASTORT Francisco
artículos
Título:
mRNA of cytokines in bone marrow and bone biomarkers in response to propranolol in a nutritional growth retardation model.
Autor/es:
DEBORAH R. TASAT; CHRISTIAN E. LEZÓN; FRANCISCO ASTORT; PATRICIA M. PINTOS; ELISA V. MACRI; SILVIA M. FRIEDMAN; PATRICIA M. BOYER
Revista:
PHARMACOLOGICAL REPORTS
Editorial:
POLISH ACAD SCIENCES INST PHARMACOLOGY
Referencias:
Año: 2014
ISSN:
1734-1140
Resumen:
Background. The aim of this study was to assess mRNA of IL-6, TNFα and IL-10 cytokines in bone marrow, possible mediators involved in altered bone remodeling with detrimental consequences on bone quality in NGR rats. Methods. Weanling male Wistar rats were assigned either to control (C) or experimental group (NGR) of 20 animals each. C and NGR groups were assigned to 2 groups according to receiving SS or propranolol (P): C, C + P (CP), NGR or NGR + P (NGRP). NGR and NGRP rats received, for 4 wk, 80% of the amount of food consumed by C and CP, respectively, the previous day, corrected by body weight. P (7mg/kg/day) was injected ip 5 days per week, for 4 wk in CP and NGRP rats. Body weight and length were recorded. After 4 wk, blood was drawn. Femurs were dissected for RNA isolation and mRNA cytokines assays. Results. Food restriction induced a highly significant negative effect on body growth in NGR and NGRP rats (p0.05). sCTX increased in NGR rats vs. C (p
