Bone health in patients with Multiple Sclerosis. Analysis of bone mineral density and 3D-reconstruction of proximal femur by DXA

ULLA MR; VRECH C; BRUN LR; BRANCE ML; PERALTA LÓPEZ E; CASTRO MJ; MARTOS F; MAZZINI S; RIVOIRA MA

Congreso; WCO-IOF-ESCEO 2021; 2021

WCO-IOF-ESCEO

Relapsing-remitting multiple sclerosis (RRMS) is an autoimmune demyelinating disease affecting 17-18 per 100000 Argentinians. Corticosteroid treatment increase bone-damaging and the rate of falls and fractures. The aim of our study was to evaluate bone health through bone mineral metabolism and bone mineral density (BMD) in RRMS-patients compared to healthy controls. Materials and methods: Observational, prospective and open study in 40 RRMS-patients aged 16-59 years and 40 matched controls (C). Serum levels of calcium, ionic calcium, phosphorus, magnesium, alkaline phosphatase, PTH, osteocalcin, β-crosslaps and 25-(OH)-vitamin D were evaluated. BMD (g/cm2) was measured by DXA on lumbar spine (LS), femoral neck (FN) and total hip (TH). 3D analysis was performed with 3D-Shaper software (Galgo Medical, Spain). A survey of physical activity, sun exposure and daily consumption was carried out. Shapiro-Wilk test and parametric or non-parametric tests were used. Data were expressed as mean±SD; p0.05; FN: C 0.817±0.123 vs RRMS 0.794±0.140, p>0.05; TH: C 0.926±0.127 vs RRMS 0.908±0.131, p>0.05). In addition, the 3D analysis of the hip showed no differences: sDens (mg/cm2): C 161.8±22.2 vs RRMS 161.0±24.3 p>0.05; trab vBMD (mg/cm3): C 206.7±42.3 vs RRMS 203.5±44.5 p>0.05). Patients with RRMS had lower serum levels of 25-(OH)-vitamin D and alkaline phosphatase (21.1±7.8 vs 38.3±14.8 ng/ml and 84.6±36.9 vs 136.3±51.7 U/L, p