Intestinal everted sacs

BRUN LR; BRANCE ML; DE CANDIA LF; RIGALLI A

Experimental Surgical Models in the Laboratory Rat

CRC Press - Taylor and Francis Group

Lugar: Boca Ratón, FL. USA; Año: 2009; p. 99 - 101

This technique is useful to study the intestinal absorption of substances, their interaction with other components of the intestinal content, the mechanism involved in its degradation in the intestinal lumen, or the pharmacological actions on the cells of the intestinal mucosa. This experiment shares several characteristics with the normal in situ isolation of intestinal loop, described in this section. As a disadvantage and a difference from the normal in situ isolated intestinal loop, the intestinal everted sacs are separated from the animal, without keeping the irrigation and the innervation of the organ. However, it allows making measures easily on the luminal compartment because its volume can be modified according to experimental conditions.