INVESTIGADORES
BRUN Lucas Ricardo Martin
artículos
Título:
Messages from the mineral: how bone cells communicate with other tissues
Autor/es:
PLOTKIN LI; SANZ N; BRUN LR
Revista:
CALCIFIED TISSUE INTERNATIONAL
Editorial:
SPRINGER
Referencias:
Lugar: Berlin; Año: 2023
ISSN:
0171-967X
Resumen:
Bone is a highly dynamic tissue, and the constant actions of bone forming and bone resorbing cells are responsible for attaining peak bone mass, maintaining bone mass in the adults, and the subsequent bone loss with aging and menopause, as well as skeletal complications of diseases and drug side-effects. It is now accepted that the generation and activity of bone forming osteoblasts and bone resorbing osteoclasts is modulated by osteocytes, osteoblast-derived cells embedded in the bone matrix. The interaction among bone cells occurs through direct contact and via secreted molecules. In addition to the regulation of bone cell function, molecules released by these cells are also able to reach the circulation and have effects in other tissues and organs in healthy individuals. Moreover, bone cell products have also been associated with establishment or progression of diseases, including cancer and muscle weakness. In this review, we will discuss the role of bone as an endocrine organ, and the effect of selected osteoclast, osteoblast, and osteocyte-secreted molecules on other tissues.