Editorial: Bone Inside-Out and Outside-In Signals: Control of Body Homeostasis

SANKAR U; BRUN LR; PLOTKIN LI

Frontiers in Endocrinology

Frontiers

Año: 2023

1664-2392

Bone mass is controlled by the coordinated actions of osteoblasts and osteoclasts, cells responsible for bone formation or bone resorption, respectively. It is now clear that the actions of these two cell types, as well as their differentiation from the corresponding precursor cells, is modulated by osteocytes, the cells embedded in the bone matrix. Recent findings indicate that in addition to their role in controlling bone mass, bone cells act as endocrine cells, and all cells produce factors able to regulate the function of distal organs, including muscle, pancreas, kidney and brain, among others. Conversely, hormones and growth factors produced by cells, other tissues modulate bone modeling and remodeling by altering osteoblast, osteoclast and osteocyte functions. Further, more recently studies provided evidence for a role of the gut microbiome on bone homeostasis. Understanding the molecular signature of bone cells, and how these cells are affected by circulating factors has provided new means to treat conditions with altered bone mass and strength.The purpose of this Research Topic Issue was to discuss different aspects of bone interactions with other tissues, both inside-out (from bone cells to other organs) and outside-in (from other cells/tissues to bone cells). These Research Topic included 20 articles from which 7 are originals and 13 reviews. The following is a summary of the articles included in the Research Topic Issue.