Negative association between 25-hydroxyvitamin d and inflammatory markers in rheumatologic diseases

BRANCE ML; LARROUDÉ MS; BERBOTTO G; SACNUN MP; AESCHLIMANN C; PALATNIK M; CHAVERO I; SÁNCHEZ A; BRUN LR

Actual Osteol

AAOMM

Año: 2021 vol. 17 p. 8 - 17

1669-8975

Objective: The main purpose of this study was to evaluate serum 25-hydroxyvitamin D (25OHD) levels and its association with inflammatory markers in rheumatologic diseases (RD). Methods: A cross-sectional study in 154 women with RD (rheumatoid arthritis, spondyloarthritis and other connective tissue diseases) and 112 healthy individuals as a control group (CG) were carried out. Results: No differences in serum and urine calcium, serum phosphate and urinary deoxypyridinoline were found. RD group had lower 25OHD and higher PTH compared to CG. RD group had higher C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) compared to CG. The overall mean level of 25OHD (ng/ml) was 26.3±12.0 in the CG and 19.4±6.8 in the RD group (p