Impaired proliferation as a component of the pathogenesis of follicular persistence related to cystic ovarian disease

SALVETTI NR; REY F; STANGAFERRO ML; GIMENO EJ; AMWEG AN; DÍAZ PU; ORTEGA HH

Cell Proliferation: Processes, Regulation and Disorders

Nova Science Publishers, Inc

Lugar: Nueva York; Año: 2013; p. 53 - 64

Folliculogenesis, ovulation, and the subsequent formation of the corpus luteum are complex processes that involve dramatic changes in ovarian cell function. Once initiated, follicular growth is a continuous process without resting phases, ending at ovulation. One of the main modifications in granulosa cell function is the rapid switch from the highly proliferative stage characterizing granulosa cells of preovulatory follicles to the non-proliferative, terminally differentiated phase of luteal cells. Cell cycle regulation involves a balance between several regulatory molecules, and can be altered by numerous external signals in multiple steps. Cystic ovarian disease (COD) and/or polycystic ovarian syndrome (PCOS) are disorders of the reproduction that affect many species including cattle (COD) and human beings (PCOS). In the bovine livestock, COD is an important cause of infertility characterized by anovulation, anoestrus, and the persistence of follicles with a larger diameter than the ovulatory follicle. The combination of weak proliferation indices and low apoptosis detected in follicular cysts, could explain the cause of the slow growth of cystic follicles and the maintenance of a static condition without degeneration, which leads to their persistence. These alterations might be a result of structural and functional modifications of follicular cells and could be related to hormonal changes in animals with COD.