Association between phagocytic activity of monocytes and days to conception after parturition in dairy cows when considering the hormonal and metabolic milieu

PERALTA MB; CAINELLI S; STASSI AF; ANGELI E; RENNA MS; SIGNORINI ML; GAREIS NC; DURANTE LN; REY F; ORTEGA HH; SALVETTI NR; VELÁZQUEZ MML

ANIMAL REPRODUCTION SCIENCE

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2021

0378-4320

Thenutritional conditions and immune status of dairy cows affect reproductive performance.This study was conducted with the aim to analyze the phagocytic activity (PA)and phagocytic capacity (PC) of circulating monocytes after the period oftransition from pregnancy to lactation, to evaluate possible associations withduration of time period to conception following parturition. Results indicatedPA was not associated with duration of time period to conception following parturition.In contrast, cows with a lesser PC conceived earlier (98 ± 9 days in milk, DIM)than those with a greater PC (168 ± 15 DIM). Based on these results, to analyzethe association of the hormonal and metabolic milieu with the PA and PC, theanimals were grouped considering the days to conception following parturition.In the group with the greater number of days to conception (>168 DIM), thePA was associated with concentrations of progesterone and betahydroxybutyrate (BHB)at 90 DIM and glucose at 120 DIM, whereas PC was associated with theconcentrations of progesterone, cortisol and glucose at 90 DIM, non-esterifiedfatty acids (NEFA) at 120 DIM, 17β-estradiol at 150 DIM, and 17β-estradioland BHB at 180 DIM. Overall, these results represent a new perspective relatedto the reproductive performance of dairy cows. The modifications of cellularfunctions may be useful for predicting the onset of health complications indairy cows and to manage cows in ways that result in an enhanced fertilityduring the subsequent lactational period.