Methicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in Argentina

FERNÁNDEZ S; DE VEDIA L; LOPEZ FURST MJ; GARDELLA N; DI GREGORIO S; GANAHA MC; PRIETO S; CARBONE E; ROTRYING F; STRYJEWSKI ME; MOLLERACH ME

Infection, Genetics and Evolution

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2013 vol. 14 p. 401 - 405

1567-1348

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have become a major concern worldwide. We conducted a prospective multicenter study of invasive CA-MRSA to evaluate clinical features and genotype of strains causing invasive infections in Argentina. A total of 55 patients with invasive CA-MRSA infections were included. Most patients (60%) had bloodstream infections, 42% required admission to intensive care unit and 16% died. No CA-MRSA isolates were multiresistant (resistant ≥ 3 classes of antibiotics). All isolates carried Panton-Valentine leukocidin (PVL) genes and staphylococcal cassette chromosome (SCCmec) type IV. The majority CA-MRSA strains belonged to ST30 and had identical PFGE patterns, qualifying as a clonal dissemination of a highly transmissible strain. In patients with invasive infections this clone genotyped as pulsed-field gel electrophoresis type C- ST30, SCCmec type IVc-spa type 019, PVL positive has become predominant and replaced the previously described CA-MRSA clone (PFGE type A, ST5, SCCmec type IV, spa type 311).