Factors associated with the presentation of complications in patients undergoing high-risk surgery

PENDINO JC; IBARZABAL JI; BETTINI L; DEPAOLI P; DEVUONO D; SANTUCCI N; BOTTASSO O

Mar del Plata

Congreso; LXX Reunión Anual de la SAI, 16-19 noviembre de 2022; 2022

Sociedad Argentina de Inmunología

The purpose of this consecutive prospective observational study was to assess whether some laboratory variables could be related to the development of complications in patients undergoing surgical operations at a School Hospital in Rosario city between May 2019 and January 2021 (18 women and 25 men, mean age 58 ± 9 years -SD-). A group of sex- and age-matched control individuals (n=10) was included to compare biochemical data. Evaluations were made on 0, 1-, 2-, 3-, and 7-days post-operation (PO). Hematological, hepatic, renal, acid-base profiles, and acute phase reactants, as well as pro- and anti-inflammatory cytokines (IL-1β, IL-6, IL-10, IL-17-A, IFNγ, and TNFα), were measured. There were complications in 31 patients between days 1 and 18 of the PO (mostly in the first days). By employing a non-parametric multiple comparison approach, complicated patients showed significantly higher levels of leukocytes, procalcitonin, troponin, and urea within the first 3 days of PO, even more in those with a higher number of complications. ThepH was statistically lower in patients with more severe complications (vs. those who did not have complications or were less severe). There was no difference between groups either in the presence of immunosuppression-related factors such as cytomegalovirus infection or salivary cortisol levels, but on day 7, the latter was found to increase in the complicated ones (p