Modulation of the extraneuronal cholinergic system on main innate response leukocytes

EDUARDO, COVANTES-ROSALES CARLOS; ALEJANDRA, TOLEDO-IBARRA GLADYS; GUADALUPE, DÍAZ-RESENDIZ KARINA JANICE; HERMINIA, VENTURA-RAMÓN GUADALUPE; LENIN, PAVÓN; ENRIQUE, BECERRIL-VILLANUEVA; EVANDRO, BAUER MOISÉS; BOTTASSO O; IVÁN, GIRÓN-PÉREZ MANUEL

JOURNAL OF NEUROIMMUNOLOGY

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2019 vol. 327 p. 22 - 35

0165-5728

The expression of elements of the cholinergic system has been demonstrated in non-neuronal cells, such as immune cells, where acetylcholine modulates innate and adaptive responses. However, the study of the non-neuronal cholinergic system has focused on lymphocyte cholinergic mechanisms, with less attention to its role ofinnate cells. Considering this background, the aims of this review are 1) to review information regarding the cholinergic components of innate immune system cells; 2) to discuss the effect of cholinergic stimuli on cell functions;3) and to describe the importance of cholinergic stimuli on host immunocompetence, in order to set the base for the design of intervention strategies in the biomedical field.