Dysregulated Network of Immune, Endocrine and Metabolic Markers is Associated to More Severe Human Chronic Chagas Cardiomyopathy

GONZÁLEZ, FLORENCIA; VILLAR, SILVINA; D?ATTILIO, LUCIANO; LEIVA, RODOLFO; MARQUEZ, JULIA; LIOI, SUSANA; BELOSCAR, JUAN; BOTTASSO, OSCAR; PEREZ, ANA ROSA

NEUROIMMUNOMODULATION.

KARGER

Año: 2018 p. 1 - 10

1021-7401

Individuals who are infected with Trypanosoma cruzi developchronic Chagas cardiomyopathy (CCC), which is a complicationinvolving a series of immune pathogenetic mechanisms,although an association between immune and metabolicalterations was more recently proposed. Accordingly,we investigated the immuno-metabolic response in chagasicpatients and their possible influence on CCC pathogenesis.To this end, T. cruzi-seropositive (asymptomatic or withCCC) and sero-negative individuals were studied. Serum tumournecrosis factor (TNF)-α, interleukin (IL)-6, adipocytokinesand the expression of their receptors in peripheralblood mononuclear cell (PBMC) were evaluated, togetherwith other factors influencing the immune response. CCCpatients showed major metabolic and hormonal abnormalities,in parallel with increased IL-6 and leptin serum levels.TNF-α receptor s, leptin and adiponectin receptors (ObR andAdipo-Rs respectively), as well as PPAR-γ expression inPBMCs from CCC patients were compatible with a counteractingresponse leading to an unfavourable immune-metabolicprofile. These results suggest that persistently increasedlevels of immune-metabolic pro-inflammatory mediatorsalong with the adverse endocrine anti-inflammatoryresponse of CCC individuals, may contribute to the underlyingmechanisms dealing with myocardial tissue damage.