Cytokines, growth Factors and cell adhesion receptors in the regulation of immunity to Trypanosoma cruzi

SAVINO W; VILLA-VERDE DMS; AREAS MENDES DA CRUZ D; SILVA MONTEIRO E; PEREZ A; SILVA JS; AOKI MP; BOTTASSO O; GUIÑAZU N; SILVA-BARBOSA SD; GEA S

CYTOKINE & GROWTH FACTOR REVIEWS

ELSEVIER SCI LTD

Año: 2007 vol. 18 p. 107 - 124

1359-6101

Pathophysiology of Chagas’ disease is not completely defined, although innate and adaptative immune responses are crucial. In acute infection some parasite antigens can activate macrophages, and this may result in pro-inflammatory cytokine production, nitric oxide synthesis, and consequent control of parasitemia and mortality. Cell-mediated immunity in Trypanosoma cruzi infection is also modulated by cytokines, but in addition to parasite-specific responses, autoimmunity can be also triggered. Importantly, cytokines may also play a role in the cell-mediated immunity of infected subjects. Finally, leukocyte influx towards target tissues is regulated by cytokines, chemokines, and extracellular matrix components which may represent potential therapeutic targets in infected patients. Here we will discuss recent findings on the role of cytokines, chemokines and extracellular matrix components in the regulation of innate and adaptive immunity during T. cruzi infectionTrypanosoma cruzi infection is also modulated by cytokines, but in addition to parasite-specific responses, autoimmunity can be also triggered. Importantly, cytokines may also play a role in the cell-mediated immunity of infected subjects. Finally, leukocyte influx towards target tissues is regulated by cytokines, chemokines, and extracellular matrix components which may represent potential therapeutic targets in infected patients. Here we will discuss recent findings on the role of cytokines, chemokines and extracellular matrix components in the regulation of innate and adaptive immunity during T. cruzi infection