Studies on the contribution of PPAR Gamma to tuberculosis physiopathology

DÍAZ, ARIANA; DATTILIO, LUCIANO; PENAS, FEDERICO; BONGIOVANNI, BETTINA; MASSA, ESTEFANÍA; CEVEY, AGATA; SANTUCCI, NATALIA; BOTTASSO, OSCAR; GOREN, NORA; BAY, MARÍA LUISA

Frontiers in Cellular and Infection Microbiology

Frontiers Media

Lugar: Lausanne; Año: 2023 vol. 13 p. 1 - 12

Tuberculosis (TB) is a major health problem characterized by an immuno-endocrine imbalance: elevated plasma levels of cortisol and pro- and anti-inflammatory mediators , as well as reduced levels of dehydroepiandrosterone. The etiological agent, Mycobacterium tuberculosis (Mtb), is captured by pulmonary macrophages (Mf), whose activation is necessary to cope with the control of Mtb, however, excessive activation of the inflammatory response also leads to tissue damage. Glucocorticoids (GC) are critical elements to counteract the immunoinflammatory reaction, andperoxisome proliferator-activated receptors (PPARs) are also involved in this regard. The primary forms of these receptors are PPARϒ, PPARa, and PPARb/d, the former being the most involved in anti-inflammatory responses. In this work, we seek to gain some insight into the contribution of PPARϒ in immunoendocrine-metabolic interactions by focusing on clinical studies in pulmonary TB patients and in vitro experiments on a Mf cell line.