Conjugated linoleic acid serum concentration: its relationship with the risk of developing salivary gland tumors

ACTIS AB; CITTADINI MC; CORNAGLIA P; PALMIOLI NS; JOEKES S

Shenzhen

Congreso; World Cancer Congress; 2010

International Union Against Cancer

Background: There are scarce epidemiologic studies referred to the relationship between the intake of conjugated linoleic acid (CLA)-rich foods and its tissue concentration and the risk of developing tumors. Objectives: To analyze the CLA serum concentration (Sc) in humans and its relationship with the risk of developing salivary tumors (ST). Methods: 20 ST patients (cases) and 20 controls (C) of both sexes and aged 46,6 ± 14,22 (mean ± SD) participated in this case-control based study. After the informed consent, a clinical history, a food frequency and a non-nutritional factor questionnaires were applied. The nutrition information was processed by the Interfood v.1.3 software and the CLA Sc was analyzed by gas chromatography. The Pearson`s correlation test and a logistic regression model were applied. The latter was used to calculate the odds ratio (OR) on the basis of the mean value of CLA Sc found in ST and C (0.08 mg/mL) with a 95% confidence interval (CI). An OR adjusted (aOR) by sex, tobacco use, alcohol intake and cancer family background was also calculated. Results: The mean CLA-rich food intake was 385,17 g/day in ST and 340,61 g/day in C, whereas the CLA Sc was 0,077 mg/mL and 0,089 mg/mL in ST and C, respectively. A weak correlation (r=0.30; p=0.05) between the CLA-rich food intake and its Sc was found. A weak non-statistically significant inverse association between CLA Sc and the risk for salivary tumors (aOR:1.94; IC:0.39-9.68) was observed. Conclusions: These preliminary results suggest that a low CLA Sc would be related to an increased risk for ST.