The Gonadotropin-Inhibitory Hormone; What we know and what we still have to learn from fish

DI YORIO, MARÍA PAULA; MUÑOZ-CUETO, JA; PAULLADA-SALMERÓN JA; SOMOZA GM; TSUTSUI K; P.G. VISSIO

frontiers in endocrinology

Frontiers in endocrinology

Año: 2019

Gonadotropin-inhibitory hormone, GnIH, is named because of its function in birds andmammals; however, in other vertebrates this function is not yet clearly established.More than half of the vertebrate species are teleosts. This group is characterized bythe 3R whole genome duplication, a fact that could have been responsible for the greatphenotypic complexity and great variability in reproductive strategies and sexual behavior.In this context, we revise GnIH cell bodies and fibers distribution in adult brains of teleosts,discuss its relationship with GnRH variants and summarize the few reports availableabout the ontogeny of the GnIH system. Considering all the information presented in thisreview, we propose that in teleosts, GnIH could have other functions beyond reproductionor act as an integrative signal in the reproductive process. However, further studies arerequired in order to clarify the role of GnIH in this group including its involvement indevelopment, a key stage that strongly impacts on adult life.