INVESTIGADORES
VISSIO Paula Gabriela
artículos
Título:
Melanin-concentrating hormone (MCH) system in the brain and skin of the cichlid fish, Cichlasoma dimerus: anatomical localization, ontogeny and distribution in compararision to alpha-melanocyte-stimulating hormone (αMSH) expressing cells
Autor/es:
PANDOLFI, MATÍAS; CÁNEPA, MAXIMILIANO; RAVAGLIA, M; PAZ, D; MAGGESE, M. CRISTINA; VISSIO, PAULA
Revista:
CELL AND TISSUE RESEARCH
Editorial:
SPRINGER
Referencias:
Lugar: Berlin; Año: 2003 vol. 311 p. 61 - 69
ISSN:
0302-766X
Resumen:
Abstract Distribution and development of the melaninconcentrating
hormone (MCH) system were examined
by immunocytochemistry of the brain, pituitary gland
and skin of the South American cichlid fish Cichlasoma
dimerus. In adults, the most prominent group of MCH-ir
perikarya was located in the nucleus lateralis tuberis
(NLT). Outside the NLT, in the posterior hypothalamic
region, a group of small neurons was found between the
third ventricle and the lateral ventricular recess with delicate
immunoreactive fibers that did not seem to contribute
to the pituitary innervation. MCH-ir perikarya were
identified at day 4 after hatching (AH) in a proliferating
zone of the hypothalamic floor. Pituitary innervation
could be detected at this stage. Another group of small
MCH-ir neurons, only detected in pre-juvenile stages,
originated close to the third ventricle in the medial hypothalamic
region by day 6 AH. αMSH-ir neurons were localized
in similar regions of the NLT and in the nucleus
periventricularis posterior (NPP). Free MCH-ir neuromasts
were detected in the ventral and dorsal skin of larval
heads. These epidermal sensory organs were in close
association with blood vessels and dermal melanocytes,
suggesting that MCH synthesized in larval skin might act
in an endocrine way reaching different targets and/or in a
paracrine mode regulating melanin concentration in dermal
melanocytes.