Behavioral tagging during an inhibitory avoidance task: identification of involved transmitter systems and learning tag-molecules in hippocampus-dependent long-term memory formation.

BALLARINI F; MONCADA D; MARTINEZ MC; ALEN N; H. VIOLA

Congreso; Second Joint Meeting of the Argentine Society for Neurosciences (SAN); 2010

Long term memory consolidation requires the synthesis of plasticity related protein (PRPs). In addition, we have recently shown that the stabilization of the mnemonic trace also requires the setting of a learning tag able to capture those PRPs. Therefore memory consolidation can also be achieved capturing PRPs provided by another temporal spatial closely-related event. Here we studied the involvement of glutamatergic dopaminergic and noradrenergic inputs on the setting of a learning tad and PRP-synthesis using an inhibitory avoidance (IA) training and the exploration of a novel open field (OF). We found that hippocampal dopamine D1/D5 and beta adrenergic receptors are specifically required to induce PRP synthesis. Moreover, the glutamatergic NMDA receptors were required for setting IA-learning tag which machinery required alpha CAMKII and PKA but not ERK ½ activity.