INVESTIGADORES
VIOLA Haydee Ana Maria
capítulos de libros
Título:
The Behavioral Tagging Hypothesis and Its Implications for Long-Term Memory Formation.
Autor/es:
MONCADA D; BALLARINI F; MARTINEZ MC; VIOLA H
Libro:
Synaptic Tagging and Capture: From Synapses to Behavior
Editorial:
Springer Publisher
Referencias:
Año: 2014; p. 231 - 261
Resumen:
Memories
are experience-dependent internal representations of the world that can last
from short periods of time to a whole life. The formation of long term memories
relies on several biochemical changes, which inducing modifications in the
synaptic efficiency change the way the neurons communicate each other.
Interestingly,
the formation of a lasting memory does not entirely depend on learning itself;
different events occurring before or after a particular experience can affect its
processing, impairing, improving, or even inducing lasting memories. The
overlapping of neuronal networks involved in the processing of different types
of learning might explain why different experiences interact at neuronal level.
However,
how and where this does really happen is an issue of study. In 1997, the
Synaptic Tagging and Capture (STC) hypothesis provided a strong framework to
explain how synaptic specifi city can be achieved when inducing long lasting changes
in electrophysiological models of functional plasticity. Ten years
later,
an analogous argument was used in learning and memory models to postulate the
Behavioral Tagging hypothesis. This framework provided solid explanation of how
weak events, only capable of inducing transient forms of memories, can result in
lasting memories when occurring in the context of other behaviorally relevant experiences.
The hypothesis postulates that the formation of lasting memories rely on
at least two parallel processes: the setting of a learning tag that determines
which memory could be stored and were; and the synthesis of plasticity-related
proteins, which once captured at tagged sites will allow the consolidation of a
memory for long periods of time. Therefore a weak learning, only able to induce
transient forms of memories but also capable of setting a learning tag, could
be benefi ted from the proteins synthesized by a different strong event,
processed in the same areas, by using them to consolidate its own lasting
memory.
In
this chapter we will detail the postulates and predictions of the Behavioral Tagging
hypothesis, deepen the mechanisms involved in the setting of the tag and the
synthesis of proteins, and revise the universe of experiments performed from rodents
to humans in order to discuss its implications on learning and memory
processing.