INVESTIGADORES
VIOLA Haydee Ana Maria
artículos
Título:
6-bromoflavone, a high affinity ligand for the central benzodiazepine receptors is a member of a family of active flavonoids
Autor/es:
MARDER, MARIEL; VIOLA, HAYDEE; WASOWSKI, CRISTINA; WOLFMAN, CLAUDIA; WATERMAN, PETER G.; CASSELS, BRUCE K.; MEDINA, JORGE H.; PALADINI, ALEJANDRO C.
Revista:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Editorial:
ACADEMIC PRESS INC ELSEVIER SCIENCE
Referencias:
Año: 1996 vol. 223 p. 384 - 389
ISSN:
0006-291X
Resumen:
6-Bromoflavone, obtained by bromination of flavanone, binds to central benzodiazepine receptors with a Ki = 70 nM and has a clear anxiolytic activity in mice, at 0.5 mg/kg, i.p. A survey of the structure/affinity relationship for those receptors in a series of natural and synthetic flavonoids is presented.
