INVESTIGADORES
VIOLA Haydee Ana Maria
artículos
Título:
Detection of benzodiazepine receptor ligands in small libraries of flavone derivatives synthesized by solution phase combinatorial chemistry
Autor/es:
MARDER, MARIEL; VIOLA, HAYDEE; BACIGALUPPO, JOSÉ A.; COLOMBO, MARÍA I.; WASOWSKI, CRISTINA; WOLFMAN, CLAUDIA; MEDINA, JORGE H.; RÚVEDA, EDMUNDO A.; PALADINI, ALEJANDRO C.
Revista:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Editorial:
ACADEMIC PRESS INC ELSEVIER SCIENCE
Referencias:
Año: 1998 vol. 249 p. 481 - 485
ISSN:
0006-291X
Resumen:
Solution phase combinatorial synthesis of flavone derivatives and evaluation of their affinity for the central benzodiazepine receptors is described. The libraries preparation is simple and provides a convenient method for rapid compound generation and screening. Thirty one new compounds were obtained of which the most promising, as high affinity benzodiazepine receptor ligands, were 6-bromo-3´-fluoroflavone; 6,3´-dichloroflavone; 6-bromo-3´-chloroflavone and 6-chloro-3´-bromoflavone.
