INVESTIGADORES
VIOLA Haydee Ana Maria
artículos
Título:
ISOLATION AND IDENTIFICATION OF 6-METHYLAPIGENIN, A COMPETITIVE LIGAND FOR THE BRAIN GABAA RECEPTORS, FROM VALERIANA WALLICHII D.C
Autor/es:
WASOWSKI C; MARDER M; VIOLA H; MEDINA J H; PALADINI AC
Revista:
PLANTA MEDICA
Referencias:
Año: 2002 vol. 68 p. 932 - 934
ISSN:
0032-0943
Resumen:
Using the guidance by a competitive assay for the benzodiazepine
binding site in the GABA(A) receptor, active compounds were isolated
from the rhizomes and roots of Valeriana wallichii DC. The UV, NMR and
mass spectral data permitted the identification of 6-methylapigenin.
This flavonoid has a Ki = 495 nM for the BDZ-bs and a GABA ratio of
1.6-2.0, which suggests possible agonistic properties. The calculated
percentage of 6-methylapigenin in the crude drug is in the range:
0.013% to 0.0013%.
