Hypothalamic Noradrenergic Hyperactivity and Detrimental Bone Statusin an Animal Model of Nutritional Growth Retardation

OLIVERA MI; COMPAGNUCCI GE; COMPAGNUCCI C; LEZON CE; MANDALUNIS P; HOPE S; BIANCIOTTI LG; ELVERDIN J; ALIPPI RM; VATTA MS; BOYER P

THE OPEN NUTRITION JOURNAL

BENTHAM SCIENCE PUBLISHER LTD

Lugar: SHARJA, UAE; Año: 2008 vol. 2 p. 29 - 36

1874-2882

Hypothalamic Noradrenergic Hyperactivity and Detrimental Bone Statusin an Animal Model of Nutritional Growth Retardation María I. Olivera1, Gabriela E. Compagnucci1, Cecilia V. Compagnucci1, Christian E. Lezón1,Patricia Mandalunis2, Sandra I. Hope3, Liliana G. Bianciotti4, Juan C. Elverdin1, Rosa M. Alippi1,Marcelo S. Vatta3 and Patricia M. Boyer*,1 Abstract We have studied hypothalamic noradrenergic activity in relation with bone status in a nutritional growth retardation model (ND). Control rats (C) were fed ad libitum. ND received 80% of the diet consumed by C for 4 weeks and later refed ad libitum for 8 weeks. Food restriction induced detrimental effects on body and femur weight and length (P<0.05) and bone biomechanical properties (P<0.001). Thickness of proliferative and hypertrophic zone (��m) of growth plate cartilage and bone volume (%, mean±SE) were 225.96±5.70 v. 280.70±12.52, 95.16±5.81 v. 134.60±9.30, 17.64±3.23 v. 26.80±2.03, respectively (P<0.05); anterior and posterior hypothalamus norepinephrine uptake and release and tyrosine hydroxylase activity (% of control) were 79.05±3.56, 67.00±10.00, 164.26±16.58 and 80.65±5.92, 147.00±1.00, 152.42±9.30, respectively (P<0.05). Thus, impaired biomechanical bone performance in ND could be due, in part, to the increased hypothalamic noradrenergic activity in response to restriction. Normalization of parameters with refeeding suggests no long-term side-effects in undernourished rats.