Quantitative modifications induced by angiotensin II on rat bile secretion

BIANCIOTTI LG; VATTA MS; DOMINGUEZ AE; VESCINA C; MAGARIÑOS J; FERNANDEZ BE

REGULATORY PEPTIDES

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 1994 vol. 54 p. 429 - 437

0167-0115

Angiotensin II (ANG II) effects on bile secretion were studied in the rat. ANG II (0.1 #g/kg) was injected into the jugularvein every 30 min and bile samples of 30 min were collected for 120 min. Blood arterial and portal venous pressures weresimultaneously recorded before and after the administration of ANG II. Results showed that ANG II decreased bile flowand the excretion of sodium, potassium, chloride and bile acids whereas it increased pH, bile osmolality and the excretionrate of bicarbonate and calcium. ANG II also led to a rapid increase in mean arterial pressure as well as portal venouspressure which reverted to control values within 1 min. The present results suggest that ANG II may modulate bile flowand the excretion rate of the different biliary constituents. We have previously investigated atrial natriuretic factor effectson bile secretion and although the atrial factor antagonizes most of ANG II biological actions, unexpectedly, ANG IIeffects on bile secretion were not opposite to those of atrial natriuretic peptide. The modifications induced by ANG IIon bile secretion may play an important role in pathophysiological conditions such as hypertensive states with increasedANG II circulating levels.