INVESTIGADORES
VARELA Oscar Jose
artículos
Título:
Cyclic oligomers (macroaldonolactones) from a protected D-galactonic acid monomer
Autor/es:
ROMERO ZALIZ, LORENA; VARELA, OSCAR
Revista:
TETRAHEDRON LETTERS
Editorial:
Elsevier
Referencias:
Año: 2009 vol. 50 p. 5677 - 5680
ISSN:
0040-4039
Resumen:
Dicyclohexylcarbodiimide-promoted self-condensation of 2,3:4,5-di-O-isopropylidene-D-galactonic acid (3) led to the macrocyclic oligomeric cyclo[(2,3:4,5-di-O-isopropylidene-(1,6)-D-galactonate)2] (4) and cyclo[(2,3:4,5-di-O-isopropylidene-(1,6)-D-galactonate)3] (5), having, respectively, 14- and 21-membered rings. The macrocycles 4 and 5 were also synthesized by cyclization of the respective linear dimer 11 and trimer 14 omega-hydroxy acid precursors prepared by stepwise additions of 3. Compounds 4 and 5 are biomaterials that may be described as macrolactone-cyclodextrins.
