Macroautophagy and the oncogene-induced senescence.

GRASSO D, VACCARO MI.

Frontiers in Endocrinology

Frontiers (Nature Publishing Group)

Lugar: Lausanne; Año: 2014 vol. 5 p. 1 - 7

1664-2392

Review por invitaciónFront Endocrinol (Lausanne). 2014 Sep 29;5:157. doi: 10.3389/fendo.2014.00157. eCollection 2014. Macroautophagy and the oncogene-induced senescence. Grasso D, Vaccaro MI. Author information Abstract The oncogene-induced senescence is emerging as a potent tumor suppressor mechanism and as a possible therapeutic target. Macroautophagy is intimately linked to the senescence condition setup, although its role has not been elucidated yet. Here, we discuss up-to-date concepts of senescence-related macroautophagy and evaluate the current trend of this growing research field, which has relevance in future perspectives toward therapeutic options against cancer.