Kallikrein and amylase contents in tissues from a mutant mouse model for human cystic fibrosis.

CATANZARO OL; VACCARO MI; VILA SB; MARTÍNEZ SEEBER AL; PIVETTA OH

LIFE SCIENCES

Pergamon Press

Lugar: England; Año: 1983 vol. 32 p. 825 - 831

0024-3205

Kallikrein and amylase activities are decreased in the pancreas and salivary glands from cri/cri homozygote mutant mice. Kallikrein is decreased in the cri/cri kidney too. With reference to nucleic acid concentrations there is no difference between control and mutant mice. The previously described electrolyte abnormalities of the cribriform degeneration (cri) mutant mouse, could be due to the abnormal activity of the kallikrein-kinin system on the transport mechanism of tubular cells in the organs mentioned. These findings represent a new step on our efforts to develop a useful animal model for human cystic fibrosis research.