INVESTIGADORES
STRUMIA Miriam Cristina
artículos
Título:
Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris (hydroxymethyl) aminomethane and N-isopropyl acrylamide
Autor/es:
JULIO CUGGINO; MIRIAM STRUMIA; CECILIA ALVAREZ I.
Revista:
REACTIVE & FUNCTIONAL POLYMERS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2011 vol. 71 p. 440 - 446
ISSN:
1381-5148
Resumen:
In this study, new hydrogels in rod shape were prepared from N-isopropyl acrylamide (NIPA), N-acryloyltris-(
hydroxymethyl) aminomethane (NAT) and N,N0-methylenebisacrylamide (BIS). The effect of the
incorporation of NAT into poly(N-isopropyl acrylamide) (PNIPA) structures for which the monomer composition
was varied from NIPA 100% to NAT 100% was explored. The rheological studies were used to test
their viscoelastic properties. Swelling experiments were used to test the capacity of water absorption, the
modification of the network parameters, the swelling kinetics, the temperature and pH swelling response
and n (number that determines the type of diffusion of water). NAT-containing hydrogels showed values
of n between 0.5 and 1, therefore the diffusion of water into the hydrogels was found to have a non-Fickian
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
of n between 0.5 and 1, therefore the diffusion of water into the hydrogels was found to have a non-Fickian
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
of n between 0.5 and 1, therefore the diffusion of water into the hydrogels was found to have a non-Fickian
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
incorporation of NAT into poly(N-isopropyl acrylamide) (PNIPA) structures for which the monomer composition
was varied from NIPA 100% to NAT 100% was explored. The rheological studies were used to test
their viscoelastic properties. Swelling experiments were used to test the capacity of water absorption, the
modification of the network parameters, the swelling kinetics, the temperature and pH swelling response
and n (number that determines the type of diffusion of water). NAT-containing hydrogels showed values
of n between 0.5 and 1, therefore the diffusion of water into the hydrogels was found to have a non-Fickian
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
of n between 0.5 and 1, therefore the diffusion of water into the hydrogels was found to have a non-Fickian
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
of n between 0.5 and 1, therefore the diffusion of water into the hydrogels was found to have a non-Fickian
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
incorporation of NAT into poly(N-isopropyl acrylamide) (PNIPA) structures for which the monomer composition
was varied from NIPA 100% to NAT 100% was explored. The rheological studies were used to test
their viscoelastic properties. Swelling experiments were used to test the capacity of water absorption, the
modification of the network parameters, the swelling kinetics, the temperature and pH swelling response
and n (number that determines the type of diffusion of water). NAT-containing hydrogels showed values
of n between 0.5 and 1, therefore the diffusion of water into the hydrogels was found to have a non-Fickian
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
of n between 0.5 and 1, therefore the diffusion of water into the hydrogels was found to have a non-Fickian
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
of n between 0.5 and 1, therefore the diffusion of water into the hydrogels was found to have a non-Fickian
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
0-methylenebisacrylamide (BIS). The effect of the
incorporation of NAT into poly(N-isopropyl acrylamide) (PNIPA) structures for which the monomer composition
was varied from NIPA 100% to NAT 100% was explored. The rheological studies were used to test
their viscoelastic properties. Swelling experiments were used to test the capacity of water absorption, the
modification of the network parameters, the swelling kinetics, the temperature and pH swelling response
and n (number that determines the type of diffusion of water). NAT-containing hydrogels showed values
of n between 0.5 and 1, therefore the diffusion of water into the hydrogels was found to have a non-Fickian
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
of n between 0.5 and 1, therefore the diffusion of water into the hydrogels was found to have a non-Fickian
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
of n between 0.5 and 1, therefore the diffusion of water into the hydrogels was found to have a non-Fickian
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
n (number that determines the type of diffusion of water). NAT-containing hydrogels showed values
of n between 0.5 and 1, therefore the diffusion of water into the hydrogels was found to have a non-Fickian
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.
n between 0.5 and 1, therefore the diffusion of water into the hydrogels was found to have a non-Fickian
character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that
these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at
high temperature that maintains the drug and hinders the release was controlled by the introduction of
NAT into the network, to allow a slow drug release of ibuprofen at 37 C and pH 7.4.