PHENOTYPIC AND FUNCTIONAL CHARACTERIZATION OF PERIPHERAL T CELL POPULATIONS FROM COVID-19 PATIENTS HOSPITALIZED IN HOSPITAL PRIVADO UNIVERSITARIO CÓRDOBA- ARGENTINA.

ONOFRIO L, DUTTO J, COL, AND SOTOMAYOR CE; INMUNOCOVIDCBA

Córdoba

Congreso; Reunión Conjunta se Sociedades de Biociencias. SAIC, SAI, SAFE, NANOMED; 2021

Sociedades de Biociencias. SAIC, SAI, SAFE, NANOMED

SARS-CoV-2 infection results in asymptomatic, mild or severe disease. T cells could contribute to these different outcomes, but it remains unclear whether T cell response is dysfunctional or excessive. Here, we evaluated the phenotypic and functional features of circulating T cells from a cohort of 40 COVID-19 patients (Cpts) with moderate (MOD) and severe (SEV) clinical disease (aged 21-80 years) and 14 aged matched healthy controls (HC) by FACS. All Cpts exhibited a reduced frequency of CD3+T and Tregs cells compare to HC (p< 0.05). When exhaustion was evaluated, SEV Cpts showed higher % of PD-1+ and CD39+ in T conv cells (p