Modified Secoiridoid from Acicarpha tribuliodes and Inhibition of Nitric Oxide production in LPS-Activated Macrophages.

MERAGELMAN T; SILVA GL; SALIDO-RENTERIA B; SOTOMAYOR CE; GIL RR

PHYTOCHEMISTRY

PERGAMON-ELSEVIER SCIENCE LTD

Año: 2006 vol. 20 p. 1363 - 1369

0031-9422

Bioassay-guided fractionation of Acicarpha tribuloides Juss. resulted in the isolation of an uncommon non-glycosylated secoiridoid,Acicarpha tribuloides Juss. resulted in the isolation of an uncommon non-glycosylated secoiridoid, 14 tribulolide (1), two known secoiridoid glycosides named secologanic acid (2) and vogeloside (3) as well as two natural chromones, 6,7-tribulolide (1), two known secoiridoid glycosides named secologanic acid (2) and vogeloside (3) as well as two natural chromones, 6,7- 15 dimethoxychromone (4) and 7-hydroxy-6-methoxy-chromone (5). Compounds 1?3 showed inhibition of nitric oxide production in lipo-dimethoxychromone (4) and 7-hydroxy-6-methoxy-chromone (5). Compounds 1?3 showed inhibition of nitric oxide production in lipo- 16 polysaccharide-activated macrophages; their activity is comparable to that of aminoguanidine, a classic inhibitor.polysaccharide-activated macrophages; their activity is comparable to that of aminoguanidine, a classic inhibitor. 17 2006 Published by Elsevier Ltd.2006 Published by Elsevier Ltd. 18 Keywords: Acicarpha tribuloides; Calyceraceae; Inhibition nitric oxide production; Macrophages; Secoiridoids; TribulolideKeywords: Acicarpha tribuloides; Calyceraceae; Inhibition nitric oxide production; Macrophages; Secoiridoids; Tribulolide