INVESTIGADORES
SORDELLI Daniel Oscar
congresos y reuniones científicas
Título:
La proteína A de Staphylococcus aureus induce el shedding temprano de TNFR1 in vivo.
Autor/es:
GIAI, C; GONZALEZ C; LEDO C; GAROFALO, A; SORDELLI DO; GOMEZ MI
Lugar:
Mar del Plata
Reunión:
Congreso; LX Reunión Científica Anual de la Sociedad Argentina de Inmunología (SAI).; 2012
Institución organizadora:
Sociedad Argentina de Inmunología
Resumen:
<!-- /* Font Definitions */ @font-face {font-family:Arial; panose-1:2 11 6 4 2 2 2 2 2 4; mso-font-charset:0; mso-generic-font-family:auto; mso-font-pitch:variable; mso-font-signature:-536859905 -1073711037 9 0 511 0;} @font-face {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:0; mso-generic-font-family:auto; mso-font-pitch:variable; mso-font-signature:-536870145 1107305727 0 0 415 0;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:""; margin:0cm; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman"; mso-fareast-language:EN-US;} .MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-family:Cambria; mso-ascii-font-family:Cambria; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"MS 明朝"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Cambria; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} @page WordSection1 {size:612.0pt 792.0pt; margin:70.85pt 3.0cm 70.85pt 3.0cm; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.WordSection1 {page:WordSection1;} --> Staphylococcus aureus infections are an important concern in public health due to their increasing incidence and high rates of mortality.  The S. aureus success as a pathogen is highly related to its enormous capacity to evade the host immune response. The critical role of TNF-α in the initial host defense against staphylococcal systemic infection has been demonstrated in experimental models and may partially explain the lack of significant benefits observed in clinical trials attempting to neutralize this cytokine in septic patients.  S. aureus protein A plays a key role in regulating inflammation through its ability to bind and signal through the TNF-α receptor (TNFR)1.  In this study, we demonstrate that S. aureus, via protein A mediated signaling, induces early shedding of  TNFR1 which precedes the secretion of TNF-α in vitro and in vivo.  The results obtained using a protein A deficient mutant and tnfr1-/- mice strongly suggest that the increased levels of soluble TNFR1 present during S. aureus experimental infection may neutralize circulating TNF-α and impair the host inflammatory response.  Early shedding of TNFR1 induced by protein A may constitute a novel mechanism by which S. aureus subverts the host immune response.