INVESTIGADORES
SORDELLI Daniel Oscar
congresos y reuniones científicas
Título:
La proteína A de Staphylococcus aureus induce el shedding temprano de TNFR1 in vivo.
Autor/es:
GIAI, C; GONZALEZ C; LEDO C; GAROFALO, A; SORDELLI DO; GOMEZ MI
Lugar:
Mar del Plata
Reunión:
Congreso; LX Reunión Científica Anual de la Sociedad Argentina de Inmunología (SAI).; 2012
Institución organizadora:
Sociedad Argentina de Inmunología
Resumen:
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Staphylococcus aureus infections are an important concern in public health
due to their increasing incidence and high rates of mortality. The S.
aureus success as a pathogen is highly related to its enormous capacity to
evade the host immune response. The critical role of TNF-α in the initial host
defense against staphylococcal systemic infection has been demonstrated in
experimental models and may partially explain the lack of significant benefits
observed in clinical trials attempting to neutralize this cytokine in septic
patients. S. aureus protein A plays a key role in regulating inflammation through
its ability to bind and signal through the TNF-α receptor (TNFR)1. In this study, we demonstrate that S. aureus, via protein A mediated signaling, induces early shedding
of TNFR1 which precedes the secretion of
TNF-α in vitro and in vivo.
The results obtained using a protein A deficient mutant and tnfr1-/- mice strongly
suggest that the increased levels of soluble TNFR1 present during S. aureus experimental infection may
neutralize circulating TNF-α and impair the host inflammatory response. Early shedding of TNFR1 induced by protein A
may constitute a novel mechanism by which S.
aureus subverts the host immune response.