SORDELLI Daniel Oscar
Local and systemic immunity against Streptococcus pneumoniae: humoral responses against a non-capsulated temperature-sensitive mutant
GARCIA VE; GHERARDI MM; IGLESIAS MF; CERQUETTI MC; SORDELLI DO
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
Lugar: UK; Año: 1993 vol. 108 p. 163 - 167
Temperature-sensitive mutants of Streptococcus pneumoniae were isolated after chemical mutagenesis. Intranasal immunization with temperature-sensitive mutant J/3 induced higher levels of circulating antibody than those obtained after immunization with the heat-killed parental wild type. Moreover, local immunization with mutant J/3 induced high levels of anti-S. pneumoniae IgG and IgA in the lower respiratory tract, whereas only moderate IgG (and no IgA) antibodies were detected in lung lavage fluids from mice immunized intranasally with the heat-killed strain.