INVESTIGADORES
SONCINI Fernando Carlos
artículos
Título:
PhoP can activate its target genes in a PhoQ-independent manner
Autor/es:
SERGIO LEJONA; MARÍA EUGENIA CASTELLI; MARÍA LAURA CABEZA; LINDA KENNEY; ELEONORA GARCÍA VÉSCOVI; FERNANDO C. SONCINI
Revista:
JOURNAL OF BACTERIOLOGY
Editorial:
American Society for Microbiology
Referencias:
Año: 2004 vol. 186 p. 2476 - 2480
ISSN:
0021-9193
Resumen:
The PhoP/PhoQ two-component system controls the extracellular magnesium depletion response in Salmonella enterica. Previous studies have shown that PhoP is unable to up-regulate its target genes in the absence of PhoQ function. In this work, we demonstrate that PhoP overexpression can substitute for PhoQ- and phosphorylation- dependent activation. Either high concentration of PhoP or activation via phosphorylation stimulates PhoP self-association.
