INV SUPERIOR JUBILADO
SEILICOVICH Adriana
artículos
Título:
Estrogen receptors and signaling pathways in lactotropes and somatotropes
Autor/es:
S. ZARATE; A. SEILICOVICH
Revista:
NEUROENDOCRINOLOGY
Editorial:
KARGER
Referencias:
Año: 2010 vol. 92 p. 215 - 223
ISSN:
0028-3835
Resumen:
Estrogens are crucial determinants in the regulation of anterior pituitary function and maintenance of tissue homeostasis. Estrogen actions in this gland are exerted through both classical and non-classical mechanisms of action. This review summarizes the expression of classical alpha and beta estrogen receptors and variant isoforms of estrogen receptors in anterior pituitary cell subpopulations. We also analyze estrogen receptor signaling pathways involved in estrogenic actions in the anterior pituitary gland, especially in lactotropes and somatotropes. Complex interactions between multiple signaling pathways are involved in estrogen regulation of hormone secretion, cell proliferation and cell death in this gland. Insight into these pituitary responses to estrogens would help to understand pituitary function and tumorigenesis.