GLIAL RESPONSE TO NUTRIENT DEPRIVATION IN EXPERIMENTAL MODELS OF ALZHEIMER?S DISEASE

GREGOSA, AMAL; POMILIO C; VINUESA, ANGELES; PRESA, JESSICA; WENKER, SHIRLEY; SARAVIA F; BEAUQUIS J

Mar del Plata

Congreso; Reunion Anual de la Sociedad Argentina de Investigacion Clinica; 2018

SAIC

Alzheimer?s disease is a neurodegenerative pathology clinicallycharacterized by progressive and irreversible cognitive decline. Dietaryrestriction (DR) has been proposed as a possible neuroprotectivestrategy able to increase neurotrophic factors levels, enhancelife span, promote autophagy and reduce oxidative stress. Ourprevious results demonstrated that transgenic animals modellingAlzheimer?s disease and exposed to DR reverted cognitive impairment,showed a reduction of amyloid beta plaque load in the hippocampusand presented an increase in hippocampal neurogenesis.Our present objective was to evaluate the glial response to nutrientrestriction in adult PDAPP-J20 transgenic (Tg) mice and in an invitro approach. The in vivo experiment consisted in a periodic DRprotocol alternating ad libitum periods (9 days) with DR periods (5days, 60% daily intake) for 1.5 months, from 6.5 to 8 months of age.We found that microglial soma size, morphological parameter compatiblewith cell activation, was increased in Tg mice (p