AMYLOID-β INDUCES ENDOTHELIAL ENDOPLASMIC RETICULUM STRESS IN ASSOCIATION WITH BLOOD-BRAIN BARRIER DISRUPTION IN EXPERIMENTAL MODELS OF ALZHEIMER’S DISEASE

POMILIO C; PRESA J; GONZALEZ PEREZ N; VINUESA A; BENTIVEGNA, MELISA; GREGOSA, AMAL; GALVAN V; BEAUQUIS J; FLAVIA EUGENIA SARAVIA

Congreso; Reunion Anual de la Sociedad Argentina de Investigacion Clinica; 2020

SAIC

Alzheimer’s disease (AD) is the leading cause of dementia. Amongother histopathological hallmarks, it is characterized by the abnormalaccumulation of Amyloid-β (Aβ) peptides. Vascular alterationsand blood-brain barrier disruption are also evidenced in AD patients,in close association with perivascular amyloid deposits, which arecomposed mainly of Aβ 1-40. In this study we characterized the progressionof vascular alterations in the hippocampus of PDAPP-J20mice, a validated transgenic model for AD. We found a significantincrement in morphological alterations in vessels from AD micecompared to age-matched controls (p