ALZHEIMER´S DISEASE AS A METABOLIC PATHOLOGY: INFLAMMATION AND INSULIN RESISTANCE IN A MOUSE MODEL OF AD. IN VIVO AND IN VITRO APPROACHES

BENTIVEGNA, MELISA; GREGOSA, AMAL; VINUESA A; POMILIO C; PRESA J; FLAVIA EUGENIA SARAVIA; BEAUQUIS J

Congreso; Reunion Anual de la Sociedad Argentina de Investigacion Clinica; 2020

SAIC

Insulin resistance and chronic inflammation are frequently associatedwith the development of cognitive disorders and neurodegenerativediseases such as Alzheimer’s disease (AD). However, it isnot yet clear whether there is a causal link between these two factors,and which one appears earlier in the pathology. Our objectivewas to study metabolic parameters and inflammation in a possiblebrain insulin resistance context in a transgenic model of AD, thePDAPP-J20 mouse at the age of 8 months. We hypothesized thatan inflammatory environment could trigger insulin resistance in thebrain, neurodegeneration and cognitive impairment. We found lowerglycemic levels and altered phosphorylation levels of AKT measuredby Western Blot -an indicator of the insulin signaling status- inthe hippocampus of transgenic mice compared with control mice(p