ASTROCYTIC INSULIN SIGNALING AND INFLAMMATION IN EXPERIMENTAL ALZHEIMER’S DISEASE

BENTIVEGNA M; GREGOSA, AMAL; ROSSI, SOLEDAD P.; VINUESA A; BONAVENTURA MM; POMILIO C; PRESA J; LUX LANTOS V; FLAVIA EUGENIA SARAVIA; BEAUQUIS J

Congreso; Reunion Anual de la Sociedad Argentina de Investigacion Clinica; 2021

SAIC

Insulin resistance (IR) and chronic inflammation are associated withthe development of cognitive disorders and neurodegenerative diseasessuch as Alzheimer’s (AD). However, it is not clear whetherthere is a causal link between these factors, which one appearsearlier in the pathology or if either one of them is triggered by theincreasing circulating levels of Aβ or amyloid deposits in early AD.Our objective was to study the metabolic and inflammatory statusof a model of AD, the PDAPP-J20 mouse at the age of 8 months.We also treated a WT group with a high fat diet (HFD) as a positivecontrol for IR. Our hypothesis was that in early stages of AD, thebrain develops IR with astrocytes showing reactivity and impairedinsulin signaling. Final body weight, glycemia and insulinemia werenot affected by genotype or HFD. The open-field test showed ananxious-like behavior in transgenic and in HFD-fed mice. Insulinsignaling measured by pAkt/Akt ratio was decreased in the hippocampusof AD mice (p