Hypolipidemic potential of Sorocea bonplandii aqueous extract in aged rats

GRANDE M.V.; GODOY C.J:; SÁNCHEZ S.S.; YANKELEVICH C.; HONORÉ S.M.

Horco Molle, Tucumán

Congreso; XXXIV Annual Scientific Meeting of the Tucuman Biology Association; 2017

Asociación de Biología de Tucumán

Hyperlipidemia is one of the main complications associated with aging. Elevated levels of plasma cholesterol (TC), particularly LDL cholesterol (LDL-c) and triglycerides (TG), are known to be associated with an enhanced risk of atherosclerosis and coronary heart disease. The aim of this study was to determine if the aqueous leaf extract of S. bonplandii leaves has hypolipidemic properties in rodents. In order to determine the activity and the effective dose of two 10% aqueous extracts (infusion and decoction), normal Wistar rats were orally administered with 72mg/kg bw and 140mg/kg bw of both extracts for 30 days (n=4 rats/group). Rosuvastatin (1 mg/kg bw) was used as a positive control. Administration of low and high doses of S. bonplandii decoction caused a significant decrease in plasma levels of TG, TC and LDL-c (p0.05). However, it reduced TG, LDL-c, VLDL-c levels and liver weight in treated animals (p