INVESTIGADORES
SALOMON Claudio Javier
artículos
Título:
13C and 15N solid-state NMR studies on albendazole and cyclodextrin albendazole complexes
Autor/es:
FERRERIRA M.; GARCÍA A.; LEONARDI D.; SALOMON C.J.; LAMAS M.C.; NUNEZ T.
Revista:
CARBOHYDRATE POLYMERS
Editorial:
ELSEVIER SCI LTD
Referencias:
Lugar: Amsterdam; Año: 2015 vol. 123 p. 130 - 135
ISSN:
0144-8617
Resumen:
13C and 15N solid-state nuclear magnetic resonance (NMR) spectra were recorded from albendazole (ABZ) and from ABZ:β-cyclodextrin, ABZ:methyl-β-cyclodextrin, ABZ:hydroxypropyl-β-cyclodextrin and ABZ:citrate-β-cyclodextrin, which were prepared by the spray-drying technique. ABZ signals were typical of a crystalline solid for the pure drug and of an amorphous compound obtained from ABZ:cyclodextrin samples. Relevant spectral differences were correlated with chemical interaction between ABZ and cyclodextrins. The number and type of complexes revealed a strong dependence on the cyclodextrin group substituent. Solid-state NMR data were consistent with the presence of stable inclusion complexes.
