Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy

MAMONE, L; SAENZ, D; VALLECORSA, P; BATLLE, A; CASAS, A; DI VENOSA, G

INTERNATIONAL JOURNAL OF PHOTOENERGY

HINDAWI PUBLISHING CORPORATION

Lugar: New York; Año: 2014 p. 1 - 8

1110-662X

a photosensitizer (PS) accumulated in the target tissue. The main disadvantage of PDT is PS retention after treatment during longtime periods that conduces to cutaneous damage. It is believed that singlet oxygen is responsible for that skin photosensitization.The aim of this work was to evaluate the photoprotective activity of the methanolic extract of the Argentinian plant Collaeaargentina against PDT under several treatments and employing different PSs. C. argentina exhibited photoprotective activity againstaminolevulinic acid- (ALA-) PDT in the LM2murine adenocarcinoma cell line. The photoprotection was dependant on the extractconcentration and the incubation time, being detectable from 40 𝜇g/mL onwards and at least after 3h exposure of the cells. C.argentina extract protects these mammalian tumor cells against PDT effects, and it interferes with the oxygen singlet productionfrom PSs during PDT treatment.We propose that it will be a promising agent to protect cells against PDT-induced skin sensitivity.