Molecular Neurobiology of Memory in Neohelice

FELD, MARIANA; MEDINA, CANDELA; ROMANO, ARTURO; FREUDENTHAL, RAMIRO

Neohelice granulata: a model species for biological studies on crustaceans.

Cambridge Scholars Publishing.

Lugar: Cambridge; Año: 2019;

Memory consolidation, reconsolidation and extinction require the activation of several transduction pathways that lead to post-translational modifications of synaptic proteins and to gene expression regulation. These molecular processes promote stabilization of the memory trace in neurons of activated circuits. We study such molecular mechanisms in the the context-signal associative learning paradigm of the crab Neohelice granulata. The role of different molecular pathways such as cAMP-dependent protein kinase (PKA), extracellular-signal regulated kinase (ERK) and nuclear factor kappa B (NF-kappaB) transcription factor pathway was analyzed. We also studied the ubiquitin-proteasome system of protein degradation, epigenetic mechanisms like histone acetylation and the role of synaptic proteins such as amyloid beta precursor protein and NMDA receptors. This chapter review the most salient results obtained over two decades of research on molecular processes in this memory model.