INVESTIGADORES
RODRIGUEZ Georgina Emma
artículos
Título:
Effects of chronic administration and withdrawal of sodium barbitone on protein synthesis of rat brain
Autor/es:
J. R. LEITE; G. RODRÍGUEZ DE LORES ARNAIZ
Revista:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 1978 vol. 8 p. 323 - 326
ISSN:
0091-3057
Resumen:
Pharmacol Biochem Behav. 1978 Apr;8(4):323-6.Effect of chronic administration and withdrawal of sodium barbitone on protein synthesis of rat brain.Leite JR, Arnaiz GR.AbstractAfter chronic administration of sodium barbitone to rats, a marked increase incorporation of [14C]-Leucine into isolated nerve endings was observed. Withdrawal of the drug resulted in a decreased incorporation with respect to values obtained with chronic ingesting animals. On the other hand chronic administration of the barbiturate produced a decreased incorporation in mitochondrial and microsomal fractions. These results are discussed in relation to the development of tolerance and abstinence syndrome to this drug.
