INVESTIGADORES
RODRIGUEZ Georgina Emma
artículos
Título:
Inhibition "in vitro" of protein synthesis in brain subcellular fractions by the convulsant 3 mercaptopropionic acid
Autor/es:
G. RODRÍGUEZ DE LORES ARNAIZ; B. ROBIOLO DE ESTEVES; M. MISTRORIGO DE PACHECO
Revista:
BIOCHEMICAL PHARMACOLOGY
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 1975 vol. 24 p. 2307 - 2309
ISSN:
0006-2952
Resumen:
The effect of the convulsant, 3-mercaptopropionic acid (MP) on [14C] leucine incorporation into proteins by brain subcellular fractions was studied. It was observed that this drug decreased protein synthesis by isolated nerve endings and mitochondria; on the other hand, microsomal fractions were not affected. The inhibition of mitochondrial protein synthesis produced by MP was not observed in the presence of an ATP-generating system. It was also found that mitochondrial ATPase was inhibited by MP. All these findings suggested that the inhibition of protein synthesis described in this paper could be an indication of an impairment of energy supply.
